The substance in RICE MIND that helps to relieve ache due to migraine is magnesium.  According to many researches, people get migraine because the level of magnesium is lower than usual.  From experiment, 21 migraine patients from 40 who receive immediate magnesium into blood vessels can be rid of headache and the rest become relieved.  It is believed that magnesium helps to maintain blood vessels and nervous system.